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Copper binding properties of a tau peptide associated with Alzheimer's disease studied by CD, NMR, and MALDI-TOF MS

✍ Scribed by Qingfeng Ma; Yanmei Li; Jintang Du; Huadong Liu; Kenji Kanazawa; Tadashi Nemoto; Hiroshi Nakanishi; Yufen Zhao

Book ID
116830963
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
323 KB
Volume
27
Category
Article
ISSN
0196-9781

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✍ Qing-Feng Ma; Yan-Mei Li; Jin-Tang Du; Kenji Kanazawa; Tadashi Nemoto; Hiroshi N πŸ“‚ Article πŸ“… 2005 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 215 KB πŸ‘ 2 views

## Abstract The tau protein plays an important role in some neurodegenerative diseases including Alzheimer's disease (AD). Neurofibrillary tangles (NFTs), a biological marker for AD, are aggregates of bundles of paired helical filaments (PHFs). In general, the α‐sheet structure favors aberrant prot