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Copolymers of 1,5-dioxepan-2-one and L- or D,L-dilactide: Hydrolytic degradation behavior

✍ Scribed by A. Löfgren; A.-C. Albertsson

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
766 KB
Volume
52
Category
Article
ISSN
0021-8995

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✦ Synopsis

The degradation of two series of copolymers made of 1,5-dioxepan-2-one (DXO) and Lor D,L-dilactide has been investigated. In uitro degradation of the six copolymers with different ratios of the ingoing components was followed using size exlusion chromatography ( SEC) , nuclear magnetic resonance (NMR) spectrometry, Fourier transform infrared (FTIR) spectroscopy, and differential scanning calorimetry (DSC) . The copolymers with a high content of lactic acid units showed a higher rate of hydrolysis than the DXO-rich copolymers. The copolymer morphology also affects the rate of degradation as seen in the differences between amorphous and semicrystalline samples. The effect of electron beam sterilization was studied as well as the degradation products formed using the gas chromatography-mass spectrometry (GC-MS ) technique. The major degradation products resulted from ester bond cleavage. Kinetics of the in uitro degradation indicate a complex hydrolysis, probably a mixture of an uncatalyzed and catalyzed mechanism. 0 1994 John Wiley & Sons, Inc.

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