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Copolymerization kinetics of N-carboxyanhydrides of some α-amino acids: Influence of nature of amino acids

✍ Scribed by M. Atreyi; M. V. R. Rao; Satish Kumar

Publisher
Wiley (John Wiley & Sons)
Year
1983
Tongue
English
Weight
334 KB
Volume
22
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Studies on copolymerization kinetics of N‐carboxyanhydride (NCA) of O‐acetyl‐L‐tyrosine (T) with NCAs of L‐valine (V) and glycine (G) were carried out in dioxane at 25°C with n‐butylamine as initiator. The reactivity ratios for the VT system were found to be r~V~:r~T~:0.57:0.22; and for the GT system, r~G~:r~T~:0.26:0.42. A comparison of this data with that obtained when L‐analine was used in place of L‐valine or glycine showed that in the three systems, the reactivity ratio of the amino acid residue with a greater tendency to form ordered secondary structure was greater than that of its comonomer. Among the variable comonomers (glycine, L‐alanine, L‐valine) of O‐acetyl‐L‐tyrosine, it is again L‐alanine, whose tendency to form helical structure is very high, that has the greater reactivity ratio.

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