✦ LIBER ✦
Cope rearrangement of Δ3,8-taxane tricarbocycles: Remarkable solvent effect on product distribution
✍ Scribed by Hiroyuki Kusama; Koichiro Morihira; Toshiyuki Nishimori; Takashi Nakamura; Isao Kuwajima
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 264 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Cope rearrangement of the taxane-like tricyclic compounds having a 1,5-diene moiety readily takes place to give novel spirocyclic compounds. This transformation is found to be reversible and the product distribution is greatly dependent on the solvent polarity: the reactions in chloroform afford the taxane-like tricarbocycles, while those in methanol give the spirocyclic compounds exclusively.