𝔖 Bobbio Scriptorium
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COP9 signalosome revisited: a novel mediator of protein degradation

✍ Scribed by Claus Schwechheimer; Xing-Wang Deng


Book ID
114322587
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
157 KB
Volume
11
Category
Article
ISSN
0962-8924

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Degradation of the LDL receptors by PCSK
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## Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) post-transcriptionally degrades the low density lipoprotein receptors (LDLR). However, it is unknown whether PCSK9 acts directly on the LDLR or if PCSK9 activates another protein that in turn causes degradation of the LDLR. ## Res