Coordinating Properties of Pyrone and Pyridinone Derivatives, Tropolone and Catechol toward the VO2+ Ion: An Experimental and Computational Approach
✍ Scribed by Daniele Sanna; Péter Buglyó; Linda Bíró; Giovanni Micera; Eugenio Garribba
- Book ID
- 102831843
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 720 KB
- Volume
- 2012
- Category
- Article
- ISSN
- 1434-1948
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✦ Synopsis
The interaction of the VO 2+ ion with pyrone derivatives and tropolone, which form very effective antidiabetic compounds, is critically re-examined. The binary systems with ethylmaltol (Hema) and tropolone (Htrop) were studied in aqueous solution and in the solid state through the combined application of spectroscopic (EPR, UV/Vis and IR) and pHpotentiometric techniques. The results were compared with those of the systems with maltol (Hma) and kojic acid (Hkoj) and rationalized on the basis of DFT simulations. All the ligands L -form [VOL] + , cis-[VOL 2 (H 2 O)] and cis-[VOL 2 (OH)] - species in aqueous solutions and a square-pyramidal [VOL 2 ] complex in the solid state, which transforms into cis-[VOL 2 -(solvent)] when it is dissolved in water or in a coordinating solvent. The coordinating properties of the ligands studied were compared with those of pyridinone [3-hydroxy-1,2-dimethyl-4(1H)pyridinone (Hdhp), and 1,2-diethyl-3-hydroxy-4(1H)pyridinone (Hdepp)] derivatives and catechol (H 2 cat),