✦ LIBER ✦

Cooperativity in monomeric enzymes with single ligand-binding sites

✍ Scribed by Carol M. Porter; Brian G. Miller

Book ID: 119196175
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 347 KB
Volume: 43
Category: Article
ISSN: 0045-2068
DOI: 10.1016/j.bioorg.2011.11.001

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Is it possible to discriminate between n

Is it possible to discriminate between negative cooperativity and ligand binding to independent sites with different affinity?

✍ Francesco Malatesta; Paolo Ascenzi 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 154 KB

A Graphical Method for Determining the N

A Graphical Method for Determining the Number of Essential Sites in Enzymes with Multiple Binding Sites for a Ligand

✍ Z.X. Wang; D.K. Srivastava 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 1003 KB

We offer a novel graphical method for determining the number of essential sites in enzymes that contain multiple binding sites for a ligand. This method is applicable both to monomeric enzymes containing multiple "unspecific" sites (for protons, metal ions, etc.) and to oligomeric enzymes containing

Several cooperating binding sites mediat

Several cooperating binding sites mediate the interaction of a lysosomal enzyme with phosphotransferase

✍ Tikkanen, R. 📂 Article 📅 1997 🏛 Nature Publishing Group 🌐 English ⚖ 408 KB

Thermodynamic and Kinetic Cooperativity

Thermodynamic and Kinetic Cooperativity in Ligand Binding to Multiple Sites on a Protein: Ca2+Activation of an ATP-Driven Ca Pump

✍ Charles Tanford, Jacqueline A. Reynolds and Edward A. Johnson 📂 Article 📅 1985 🏛 National Academy of Sciences 🌐 English ⚖ 721 KB

The Origins of Femtomolar Protein−Ligand

The Origins of Femtomolar Protein−Ligand Binding: Hydrogen-Bond Cooperativity and Desolvation Energetics in the Biotin−(Strept)Avidin Binding Site

✍ DeChancie, Jason; Houk, K. N. 📂 Article 📅 2007 🏛 American Chemical Society 🌐 English ⚖ 498 KB

Inhibition Effects in the Hydrolysis Rea

Inhibition Effects in the Hydrolysis Reactions of Esters and Peptides Catalyzed by Carboxypeptidase A: An Example of Cooperative Binding Effects with a Monomeric Enzyme

✍ Abdulkader Rahmo; Thomas H. Fife 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 151 KB

N-benzoyl-L-phenylalanyl-L-phenylalanine is an excellent peptide substrate for carboxypeptidase A; at 30°C and pH 7.5, K m is 2.6 × 10 -5 M while k cat is 177 s -1 (k cat /K m = 6.8 × 10 6 M -1 s -1 ). Indole-3-acetic acid is a noncompetitive or mixed inhibitor towards the peptide and toward hippury