𝔖 Bobbio Scriptorium
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Cooperativity during the Formation of Peptide/MHC Class II Complexes †

✍ Scribed by Anderson, Matthew W.; Gorski, Jack


Book ID
125832441
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
277 KB
Volume
44
Category
Article
ISSN
0006-2960

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The presentation of antigenic peptides by MHC class II molecules is essential for activation of CD4+ T cells. The formation of most peptide-MHC-class-II complexes is influenced by the actions of two specialized accessory proteins--DM and DO--located in the endosomal/lysosomal system where peptide lo