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Cooperative transformation of NIH3T3 cells by Gα12 and Rac1

✍ Scribed by Tolkacheva, Tatyana; Feuer, Barry; Lorenzi, Matthew V; Saez, Rosana; Chan, Andrew M-L

Book ID
110060832
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
570 KB
Volume
15
Category
Article
ISSN
0950-9232

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## Abstract Activating Ras mutations are involved in a significant fraction of human tumors. A suppressor screen using a retroviral mouse fibroblast cDNA library was performed to identify novel factors in Ras‐mediated transformation. We identified a novel potent inhibitor of Ras‐mediated morphologi