Cooperative effects in the peptidyltransferase center of Escherichia coli ribosomes
β Scribed by Saul B. BOURD; Marina K. KUKHANOVA; Boris P. GOTTIKH; Alexander A. KRAYEVSKY
- Book ID
- 118701386
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 622 KB
- Volume
- 135
- Category
- Article
- ISSN
- 1432-1327
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π SIMILAR VOLUMES
Two spontaneous mutants of Escherichia coli strain KMBL-146 selected for resistance to the aminoglycoside antibiotic neamine show severe restriction of amber suppressors in vivo. Purified ribosomes from the mutant strains exhibit low neamine-induced misreading in vitro and a decreased affinity for t
Protein S5 and S12 were isolated from 30S ribosomal subunits of two E. coli mutants highly resistant to the antibiotic neamine, and of the parental strain. Proteinchemical analyses on these proteins led to the following results: a) In protein S5 the arginine residue in peptide T2 of the parental str