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Cooperative benefit for the combination of rapamycin and imatinib in tuberous sclerosis complex neoplasia

✍ Scribed by Govindarajan, Baskaran; Willoughby, Laura; Band, Hamid; Curatolo, Adam S; Veledar, Emir; Chen, Suephy; Bonner, Michael Y; Abel, Martin-Garrido; Moses, Marsha A; Arbiser, Jack L

Book ID
119914799
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
280 KB
Volume
4
Category
Article
ISSN
2045-824X

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## Abstract Tuberous sclerosis complex (TSC) is a familial tumor syndrome characterized by the development of hamartomas in the brain, heart, kidney, and skin. Disease‐causing mutations in the __TSC1__ or __TSC2__ gene result in constitutive activation of the highly conserved mTOR signal transducti