Cooperation of Toll-like receptor signals in innate immune defence
β Scribed by Trinchieri, Giorgio; Sher, Alan
- Book ID
- 109955640
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 504 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1474-1741
- DOI
- 10.1038/nri2038
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## Abstract Signal transduction through Tollβlike receptors (TLRs) has been one of the main topics in immunology research in recent years. Because of their signaling particularities based on the homotypic recognition of protein domains in multiple adaptors and selective activation of protein kinase
During infection or tissue damage, the innate immune system detects and responds to nucleic acids released from pathogens or damaged host cells. Accumulating evidence has showed that specific sequences, modifications or structures of nucleic acids influence their immunomodulatory activities. Resulti