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Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway

✍ Scribed by Oleinik, N V; Krupenko, N I; Krupenko, S A

Book ID
110072521
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
356 KB
Volume
26
Category
Article
ISSN
0950-9232

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## Abstract Exposure of mammalian cells to genotoxic stress results in activation of the c‐jun amino‐terminal kinase (JNK)‐stress‐activated protein kinase (SAPK) pathway and induction of DNA repair enzymes and cell cycle–regulatory proteins such as p53 and __p21waf1__. The p53 tumor suppressor prot