Converting the prion protein: What makes the protein infectious
β Scribed by Ilia V. Baskakov; Leonid Breydo
- Book ID
- 116270504
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 488 KB
- Volume
- 1772
- Category
- Article
- ISSN
- 0925-4439
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## Abstract Neuroglobin and cellular prion protein (PrP^C^) are expressed in the nervous system and coβlocalized in the retinal ganglion cell layer. Both proteins do not have an unambiguously assigned function, and it was recently reported that PrP^C^ aggregates rapidly in the presence of neuroglob
Newly made polypeptide chains require the help of molecular chaperones not only to rapidly reach their final three-dimensional forms, but also to unfold and then correctly refold them back to their biologically active form should they misfold. Most prions are an unusual type of protein that can exis