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Conversion of spironolactone to canrenone and disposition kinetics of spironolactone and canrenoate-potassium in rats

✍ Scribed by W. Sadée; U. Abshagen; C. Finn; N. Rietbrock

Book ID
112342562
Publisher
Springer-Verlag
Year
1974
Tongue
English
Weight
748 KB
Volume
283
Category
Article
ISSN
0028-1298

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✍ Amitava Dasgupta; Myrtle J. Johnson 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB

## Abstract Spironolactone, a potassium sparing diuretic metabolized to canrenone, is often used with digoxin to treat various conditions including congestive heart failure. Potassium canrenoate is a similar drug that is also metabolized to canrenone. Due to reported interference of spironolactone,