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Conversion of Phospholamban into a Soluble Pentameric Helical Bundle †

✍ Scribed by Li, Huiming; Cocco, Melanie J.; Steitz, Thomas A.; Engelman, Donald M.

Book ID
126223608
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
151 KB
Volume
40
Category
Article
ISSN
0006-2960

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Cartilage oligomeric matrix protein (COMP) is a pentameric glycoprotein of the thrombospondin family found in cartilage and tendon. Self-association of COMP is achieved through the formation of a fivestranded a-helical bundle that involves 64 N-terminal residues (from 20 to 83). The complex is furth