Conversion of Non-immune Cells into Antibody-forming Cells by RNA
β Scribed by COHEN, EDWARD P.
- Book ID
- 109655361
- Publisher
- Nature Publishing Group
- Year
- 1967
- Tongue
- English
- Weight
- 474 KB
- Volume
- 213
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/213462a0
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π SIMILAR VOLUMES
## Abstract Using a quantitative assay for lymphocyteβmediated cytotoxicity, it was shown that normal, nonβimmune C3Hf/HeCr mouse spleen cells were converted to effector cells specifically cytotoxic to chemically induced C3H tumor cells by incubation in vitro with βimmuneβ RNA extracted from the ly
Normal mouse spleen cells take up in vitro radioactively labeled immune RNA. RNA taken up is present in nuclei, polysomes, membranes and cytoplasm. About 20-40% of immune RNA is nonspecifically associated with cell surface. 45% of RNA taken up is degraded and reutilized inside the cells within 2 hou