Conversion of excision-repairable DNA lesions to micronuclei within one cell cycle in human lymphocytes

Effect of camptothecin on mitogenic stim

Effect of camptothecin on mitogenic stimulation of human lymphocytes: Involvement of DNA topoisomerase I in cell transition from G0 to G1 phase of the cell cycle and in DNA replication

✍ Silvia Bruno; Walter Giaretti; Zbigniew Darzynkiewicz 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 929 KB

The possible involvement of DNA topoisomerase I in cell transition from C , to G , and in progression through the cell cycle was studied by estimating the ability of human peripheral blood lymphocytes to undergo mitogenic stimulation in the presence of the topoisomerase I inhibitor camptothecin (CAM