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Conversion of aminoglycosidic antibiotics: novel and efficient approaches to 3'-deoxyaminoglycosides via 3'-phosphoryl esters

โœ Scribed by Okutani, Tetsuya; Asako, Tsunehiko; Yoshioka, Kouichi; Hiraga, Kentaro; Kida, Makoto


Book ID
126046714
Publisher
American Chemical Society
Year
1977
Tongue
English
Weight
245 KB
Volume
99
Category
Article
ISSN
0002-7863

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A new method for synthesis of 3'-end-phosphorylated DNA oligomers via the phosphoramidite method with allyl protection has been developed. This method is particularly useful for the preparation of derivatives with base-labile structures such as oligoDNA-OPO(OH)OCH2CH(R)Z, in which Z is an electron-w