Synthesis of Constrained Peptidomimetics
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Luca Gentilucci; Alessandra Tolomelli; Rossella De Marco; Claudia Tomasini; SΓΆre
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Article
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2011
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John Wiley and Sons
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English
β 255 KB
## Abstract Sulfonyl peptides containing a serine or threonine residue undergo cyclization with bis(succinimidyl) carbonate (DSC) and diisopropylethylamine (DIPEA) to give peptides with a 2βoxoβ1,3βoxazolidineβ4βcarboxylate (Oxd) group, either in solution or in the solid phase. The position of the