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Conversion of 2(3H)-furanones into 1,3,4-oxadiazoles

โœ Scribed by Abdel-Sattar S. Hamad Elgazwy; Mayssoune Y. Zaki; Nahed N. Eid; Ahmed I. Hashem


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
85 KB
Volume
14
Category
Article
ISSN
1042-7163

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โœฆ Synopsis


Abstract

A series of 2โ€phenylโ€5โ€alkenylโ€1,3,4โ€oxadiazoles were synthesized in high yields from the corresponding dicarbonylhydrazides through cyclodehydration. ยฉ 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:570โ€“574, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10197


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Conversion of 2(3H)-Furanones into 1,3,4
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## Abstract 3โ€(2โ€alkenoyl)โ€thiocarbazic acid Oโ€methyl esters **1** are desulfurated by bromine and the unknown intermediates are transformed by alkali to 5โ€(1โ€alkenyl)โ€1, 3, 4โ€oxadiazolโ€2(3__H__)โ€ones (**2**). This type of oxadiazolone substitution is not realizable by the common ring closure of hy