Convergence of mitogenic and DNA damage signaling in the G1 phase of the cell cycle
✍ Scribed by Reuven Agami; René Bernards
- Book ID
- 117467185
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 410 KB
- Volume
- 177
- Category
- Article
- ISSN
- 0304-3835
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The possible involvement of DNA topoisomerase I in cell transition from C , to G , and in progression through the cell cycle was studied by estimating the ability of human peripheral blood lymphocytes to undergo mitogenic stimulation in the presence of the topoisomerase I inhibitor camptothecin (CAM
## Abstract Cell cycle progression is dependent upon the action of cyclins and their partners the cyclin dependent kinases (CDKs). Each cell cycle phase has its own characteristic cyclin‐CDK combination, cyclin D‐CDK4,6 and cyclin E‐CDK2 being responsible for progression through G~1~‐phase into S‐p