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Convenient Synthesis of α,β-Unsaturated Phosphonates via a Mizoroki—Heck Reaction of Arylboronic Acids with Diethyl Vinylphosphonate.

✍ Scribed by George W. Kabalka; Sankar K. Guchhait; Abhijit Naravane


Publisher
John Wiley and Sons
Year
2004
Weight
87 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract Diethyl (1‐cyanoethyl) phosphorate 1 was reacted with __n__‐butyl‐lithium in tetrahydrofuran (THF) at ‐ 78 °C and the resulting carbanion 2 reacted with perfluoroalkanoic add anhydride to afford perfluoroacylated phosphorate 3. Without isolation 3 was attacked by Grignard reagents givin