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Convenient synthesis of some 2-substituted 4(3H)-quinazolinone derivatives

✍ Scribed by I. Philipova; G. Dobrikov; K. Krumova; J. Kaneti

Publisher: Journal of Heterocyclic Chemistry
Year: 2006
Tongue: English
Weight: 125 KB
Volume: 43
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570430436

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✦ Synopsis

Abstract

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A series of 2‐substituted‐4(3__H__)‐quinazolinones 13‐20 has been synthesized in good yields using the reaction of double lithiated 2‐methylquinazolinone‐4 with a variety of aromatic aldehydes. They have been easily transformed in high yields into the corresponding 2‐substituted conjugated derivatives 21‐28 bearing terminal aryl groups by F~3~CCOOH mediated dehydration.

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