Convenient synthesis of disulfide substrates for trypanothione reductase using polymer-supported reagents

✍ Scribed by Kelly Chibale; Alex Chipeleme; Stuart Warren

• Book ID: 104250491
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 59 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00064-3

✦ Synopsis

Operationally simplified and high yielding methods for the preparation of N,N%-bis(benzyloxycarbonyl)-1-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide, an alternative substrate for trypanothione reductase, and a structural analogue, using polymer-supported reagents are described.