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Convenient synthesis of chlorohydrins from epoxides using zinc oxide: Application to 5,6-epoxysitosterol

✍ Scribed by Firouz Matloubi Moghaddam; Hamdollah Saeidian; Zohreh Mirjafary; Marjan Jebeli Javan; Mehdi Moridi Farimani; Marjan Seirafi

Book ID
102232931
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
138 KB
Volume
20
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

Efficient synthesis of protected and unprotected chlorohydrins has been achieved by ring opening of epoxides with acetyl/benzoyl chloride and TMSCl using a catalytic amount of ZnO as a reusable catalyst. The applicability of ZnO is further extended by performing the cleavage of the natural product 5,6‐epoxysitosterol with acetyl chloride. Β© 2009 Wiley Periodicals, Inc. Heteroatom Chem 20:157–163, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20529

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