Convenient Synthesis of 5,6,11,12,17,18- Hexahydrocyclononal[1,2- b :4,5- b ‘:7,8- b ‘ ‘]triindole, a Novel Phytoestrogen
✍ Scribed by Staub, Richard E.; Bjeldanes, Leonard F.
- Book ID
- 126935021
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 55 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0022-3263
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A new synthetic method to obtain the potential anticancer agent 5,6,11,12,17,18,23,24-octahydrocyclododeca[1,2-b:4,5-b 0 :7,8-b 00 :10,11-b 000 ]tetraindole (CTet), starting from 1H-indole-3-carboxaldehyde and sulfamide, is described. Although a mixture of CTet and cyclic indole trimer (CTr) is form
7,8]tetrathiacyclododecino [4,3-b:5,6-bЈ:10,9-bЈЈ:11,12-bЈЈЈ]tetraindoles 9a and 9b have been isolated in good yields, and the existence of a third conformer 9c in solution was demonstrated by mass spectrometry and 1 H NMR spectroscopy. The interconversions of the tetraindoles 9a-c have also been st