✦ LIBER ✦

Convenient synthesis of 2-deoxy-scyllo-inosose and 2-deoxy-scyllo-inosamine: two key intermediates on the biosynthetic pathway to aminoglycoside antibiotics

✍ Scribed by Jinquan Yu; Jonathan B Spencer

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 56 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00612-8

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✦ Synopsis

2-Deoxy-scyllo-inosose 1 and 2-deoxy-scyllo-inosamine 2 are two of the key intermediates on the biosynthetic pathway to 2-deoxystreptamine-containing aminoglycoside antibiotics. Convenient syntheses of 1, 2 and tritium-labelled 2 via stereoselective deoxygenation of myo-inositol using LTBH are reported. This should provide the substrates necessary for characterising the enzymes involved on the biosynthetic pathway.