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Convenient synthesis of 1,2,3,4-tetrahydro-pyrimidin-5-ylbenzoxazoles

✍ Scribed by Myung Hee Jung; Sung-Won Choi; Kui-Woong Cho

Publisher
Journal of Heterocyclic Chemistry
Year
2000
Tongue
English
Weight
392 KB
Volume
37
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

2‐Pyrimidin‐5‐ylbenzoxazoles 7 have been synthesized by condensation of 5‐pyrimidinecarboxaldehyde 4 with substituted aminophenols 5 followed by oxidative cyclization of the resulting Schiff's bases 6 with iodobenzene diacetate. Subsequent formation of methylpyrimidinium salts 8 and reduction thereafter afforded tetrahydropyrimidinylbenzoxazoles 10. This method has been utilized in the synthesis of M~1~ muscarinic agonist candidates.

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Synthesis of spiro[3,4-diaryl-4,5-dihydr
Synthesis of spiro[3,4-diaryl-4,5-dihydroisoxazole-5,2′-1′,2′,3′,4-tetrahydro-1′-naphthalenone]
✍ Santhanaraman Manikandan; Muthian Shanmugasundaram; Raghavachary Raghunathan 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 127 KB 👁 1 views

## Abstract Synthesis of a series of novel spiro[3,4‐diaryl‐4,5‐dihydroisoxazole‐5,2′‐1′,2′,3′,4′‐tetrahydro‐1′‐naphthalenone] has been described by the regioselective cycloaddition of nitrile oxides with 2‐arylmethylene‐1,2,3,4‐tetrahydro‐1‐naphthalenone. © 2001 John Wiley & Sons, Inc. Heteroatom