Convenient syntheses of pyrroloiminoquinone and its lexitropsin-linked derivative

✍ Scribed by Huiying Wang; Naim H. Al-Said; J.William Lown

• Book ID: 104214343
• Publisher: Elsevier Science
• Year: 1994
• Tongue: French
• Weight: 157 KB
• Volume: 35
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)73118-2

✦ Synopsis

The syntheses of l-4. pyrroloiminoquinone chromophora and its lexitropsin carrier linked derivative designed to improved cellular uptake are dewibed.

Marine natural products have

received increasing attention as a source of new and useful anticancer drugs. Recently, a series of publications described a new class of highly cytotoxic pyn-oloiminoquinones based on a pyrrolo[4,3,2-de]-quinoline skelecton: makaluvamines, isolated from the Fijian Sponges of the Genus Zyzzyu,l batzellines and isoba@ellines, isolated from the Caribbean sponge Barzella sp.,* damirones, isolated from Pacific sponge Damiria sp.,3 discorhabdins. isolated from New Zealand sponges of the genus L.urruncuIia.~ The makaluvamines are related structurally to other cytotoxic marine metabolites. that exhibit potent in vitro cytotoxicity toward the human colon tumor cell-line HCT 116, show differential toxicity toward 0