Convenient syntheses of adenosine 5′-diphosphate, adenosine 5′-methylenediphosphonate, and adenosine 5′-triphosphate
✍ Scribed by Vyas M. Dixit; C.Dale Poulter
- Book ID
- 104241399
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 201 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
AbhXh_ac.C Adenosine 5'-tosylate is converted to adenosine 5'-diphosphate (ADPI, adenosine 5'- methylenediphosphonate, and adenosine 5'-triphosphate (ATP) in good yields by direct displacement with the appropriate inorganic salt.
Nucleosides are normally phosphorylated by displacement at an activated phosphorus with a nucleophilic sugar hydroxyl.1-5
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The volume changes, AV. produced by the formation of two types of 1:l Cu(Ii)rdipeptide complexes were determined dilatometrically. A volume increase of about 11 ml/mole results from the formation of one category of complex in which the Cu(II) is chelated to the terminal amino and carbonyl oxygen of