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Convenient syntheses of [20,20,20-2H3]-arachidonic acid and [20,20,-2H2]-20-hydroxyeicosatetraenoic acid

✍ Scribed by J. R. Falck; Siddam Anjaiah; Venugopal Raju Tuniki; V. Raj Gopal; Jorge H. Capdevila

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
113 KB
Volume
49
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Deuterated arachidonic acid and 20‐HETE were prepared in good overall yields and high stereoselectivities. Key transformations include a trans‐specific vinyl dibromide reduction and Suzuki cross‐couplings to a lithium borate or a 9‐BBN borane. These standards are three and two mass units higher, respectively, than their naturally occurring counterparts and are useful in mass spectrometry analysis. Copyright Β© 2006 John Wiley & Sons, Ltd.

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