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Convenient procedure of Horner–Wadsworth–Emmons olefination for the synthesis of simple and functionalized α,β-unsaturated nitriles

✍ Scribed by Alessandra Lattanzi; Liliana R. Orelli; Patrizia Barone; Antonio Massa; Patrizia Iannece; Arrigo Scettri

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 799 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)02880-0

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✦ Synopsis

A mild and practical procedure of Horner-Wadsworth-Emmons olefination promoted by lithium hydroxide and a-cyano phosphonates has been set up for the synthesis of a,b-unsaturated nitriles. The reaction conditions are tolerated by functionalized ketones and the exclusive formation of E-g-hydroxy a,b-unsaturated nitriles has been observed.

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