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Convenient preparations of 2-alkyl-5-oxopyrrolidine-3-carboxylic acids

✍ Scribed by Anna D. Photiadou; Christos I. Stathakis; John K. Gallos

Publisher: Journal of Heterocyclic Chemistry
Year: 2008
Tongue: English
Weight: 211 KB
Volume: 45
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570450454

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✦ Synopsis

Abstract

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Reduction of the Michael addition products of anions of nitro compounds to dimethyl maleate led to the spontaneous formation of the respective 2‐alkyl‐5‐oxopyrrolidine‐3‐carboxylic acid methyl esters. Conventional hydrolysis of the later gave the desired compounds.

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