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Convenient preparation of 3-substituted 1(2H)-isoquinolinones

โœ Scribed by Poindexter, Graham S.


Book ID
126413762
Publisher
American Chemical Society
Year
1982
Tongue
English
Weight
256 KB
Volume
47
Category
Article
ISSN
0022-3263

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Preparation of carbon-14 labeled 3,4-dih
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## Abstract Carbonโ€14 labeled 3,5โ€dihydroโ€5โ€methylโ€1(2H)โ€isoquinolinone, a potent inhibitor of poly(ADPโ€ribose) polymerase (ADPRP) was prepared from 1โ€bromoโ€2โ€methylbenzene in 7.8 % overall yield. The Cโ€14 label was introduced from Ba^14^CO~3~ via metalโ€halogen exchange and carboxylation reactions.