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Convenient general synthetic method for 1,4- and 1,5-diketones by palladium catalyzed oxidation of α-allyl and α-3-butenyl ketones

✍ Scribed by Jiro Tsuji; Isao Shimizu; Keiji Yamamoto


Book ID
108384600
Publisher
Elsevier Science
Year
1976
Tongue
French
Weight
114 KB
Volume
17
Category
Article
ISSN
0040-4039

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Regio-and stereoselective 1,3-dipolar cycloaddition of nitrile oxide to optically active asilyl allyl alcohol provides a useful preparation of 3,4,5-trisubstituted 4,5-dihydroisoxazoles, which are readily converted into chiral 4-substituted 5,6-dihydro-4H-[ 1,2]-oxazines in 73-100% yields on treatme