We describe herein the synthesis of polybromodiphenylacetic acid (&), a fragment common to the tritiation substrates (a) and (JJ) of the sodium channel blocker, PD-85639 (1) and the angiotensin II inhibitor EXP-655 (2) respectively. Preparation of (a) and (11) followed by reductive debromonation wit
✦ LIBER ✦
Convenient and efficient tritiation of aristolochic acid I (AAI) and aristolochic acid II (AAII) with tritiated water
✍ Scribed by Tapan Ray; Amy Wu; Alban J. Allentoff
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- French
- Weight
- 67 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
Iridium‐catalysed isotope exchange with tritiated water is an efficient way to introduce tritium into polar molecules. The method is feasible for compounds containing a nitro group.It has been confirmed through our experiment that using excess tritiated water, the H/T exchange can be quantitative. Copyright © 2007 John Wiley & Sons, Ltd.
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