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Controlling Fusion and Aggregation in Polymersome Dispersions

✍ Scribed by Thomas P. Smart; Christine Fernyhough; Anthony J. Ryan; Giuseppe Battaglia

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
682 KB
Volume
29
Category
Article
ISSN
1022-1336

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✦ Synopsis

Abstract

The effects of addition of poly(ethylene oxide) (PEO) to poly(ethylene oxide)~16~‐block‐poly(butylene oxide)~22~ (EB1) polymersome dispersions has been studied. Aggregation and membrane fusion between polymersomes were observed with great control of the outcome by varying PEO molecular weight. Small‐scale fusion of 2 to 3 polymersomes was seen with low‐molecular‐weight PEO, whilst large‐scale aggregation occurred above a critical PEO molecular weight of 4 000 Da. The resulting highly porous EB1‐PEO aggregate shows great promise for applications in cell entrapment for transport and delivery, and as a three‐dimensional scaffold for use in tissue engineering.

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