Controlling biofilm formation with an N-halamine-based polymeric additive

✍ Scribed by Jie Luo; Zhaobin Chen; Yuyu Sun

• Book ID: 102293320
• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 227 KB
• Volume: 77A
• Category: Article
• ISSN: 1549-3296
• DOI: 10.1002/jbm.a.30689

✦ Synopsis

Abstract

An N‐halamine‐based polymeric additive, poly[(6‐morpholino‐s‐triazine‐2,4‐diyl)‐N‐chloro‐[2,2,6,6‐tetramethyl‐4‐piperidyl)imino]‐hexamethylene[(2,2,6,6–4‐piperidyl) imino]] (APA‐1), was prepared in this study. The chemical structure of APA‐1 was confirmed by iodometric titration, ^1^H NMR, and ^13^C NMR analysis. APA‐1 was incorporated into polyurethane through solvent casting. The resultant materials demonstrated potent antimicrobial functions against Staphylococcus epidermidis. Zone of inhibition studies showed that APA‐1 inactivated the bacteria through contact, without leaching out of the polyurethane samples. In vitro studies illustrated that APA‐1‐containing polyurethane could prevent the colonization and biofilm formation of S. epidermidis for at least 28 days. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006