Controlled Synthesis of Well Defined Poly(3-hydroxyalkanoate)s-based Amphiphilic Diblock Copolymers Using Click Chemistry
✍ Scribed by Julien Babinot; Estelle Renard; Valérie Langlois
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 427 KB
- Volume
- 212
- Category
- Article
- ISSN
- 1022-1352
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✦ Synopsis
Abstract
A modular synthesis of short chain length and medium chain length poly(3‐hydroxyalkanoate)s‐b‐poly(ethylene glycol) (PHAs‐b‐PEG) diblock copolymers is described. First, length‐controlled oligomers of hydrophobic poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBHV), poly(3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate) (PHBHHx), and poly(3‐hydroxyoctanoate‐co‐hydroxyhexanoate) (PHOHHx) containing a carboxylic acid end group were obtained by thermal treatment, with molar masses ranging from 3 800 to 15 000 g · mol^−1^. After quantitative functionalization with propargylamine, ligation with azide‐terminated poly(ethylene glycol) of 5 000 g · mol^−1^ was accomplished using the copper (I) catalyzed azide alkyne cycloaddition (CuAAC). Well‐defined diblock copolymers were obtained up to 93% yield, with molar masses ranging from 9 900 to 23 100 g · mol^−1^. All products were fully characterized using ^1^H NMR, COSY, SEC, TGA, and DSC. magnified image