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Controlled study of meso-2,3-dimercaptosuccinic acid for the management of childhood lead intoxication

✍ Scribed by Joseph H. Graziano; Nancy J. Lolacono; Thomas Moulton; Mary Ellen Mitchell; Vesna Slavkovich; Concepcion Zarate

Book ID: 117162384
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 634 KB
Volume: 120
Category: Article
ISSN: 1097-6833
DOI: 10.1016/s0022-3476(05)80618-3

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meso-Dimercaptosuccinic acid (DMSA) is the drug of choice for the treatment of lead-poisoning. DMSA is excreted in the urine of lead-poisoned rabbits as a conjugate with two molecules of cysteine. To confirm this, and to examine the hypothesis that DMSA may be acting as a pro-drug, we have synthesiz