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Controlled release using a new bioerodible polyphosphazene matrix system

✍ Scribed by Laurencin, C. T. ;Koh, H. J. ;Neenan, T. X. ;Allcock, H. R. ;Langer, Robert

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
864 KB
Volume
21
Category
Article
ISSN
0021-9304

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✦ Synopsis

Polyphosphazenes possess polymer backbones consisting of nitrogen and phosphorous formally separated by alternating single and double bonds. Their potential for biomedical applications stems from the fact that polymers with a wide array of properties can be synthesized using the same starting compound, poly(dich1orophosphazene), through changes in side chain substituents, and that many of these compounds synthesized have been found to biodegrade to harmless products. In this article, studies of a novel monolithic bioerodible polyphosphazene matrix system for controlled drug delivery are presented. Poly(imidazo1e methy1phenoxy)phosphazene is synthesized and shown to be bioerodible. The versatility of drug delivery devices fabricated using this polymer is shown through studies of release of macromolecules and low molecular weight drugs. Initial histological evaluations of this particular polyphosphazene are also presented.

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