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Controlled release of vascular endothelial growth factor using poly-lactic-co-glycolic acid microspheres: In vitro characterization and application in polycaprolactone fumarate nerve conduits

✍ Scribed by Jing Rui; Mahrokh Dadsetan; M. Brett Runge; Robert J. Spinner; Michael J. Yaszemski; Anthony J. Windebank; Huan Wang


Book ID
113416048
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
568 KB
Volume
8
Category
Article
ISSN
1742-7061

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## Abstract Regeneration of peripheral nerves after injury is suboptimal. We now report the long term delivery of nerve growth factor (NGF) by biodegradable poly‐lactic‐__co__‐glycolic acid (PLGA) microspheres __in vitro__ and __in vivo__. Lactic to glycolic acid ratios of 50:50 and 85:15 were fabr