𝔖 Bobbio Scriptorium
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Controlled release of macromolecules and pharmaceuticals from synthetic polypeptides based on glutamic acid

✍ Scribed by Kenneth R. Sidman; William D. Steber; Arthur D. Schwope; Gayle R. Schnaper

Publisher
Wiley (John Wiley & Sons)
Year
1983
Tongue
English
Weight
466 KB
Volume
22
Category
Article
ISSN
0006-3525

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✦ Synopsis

Biocompatible, biodegradable copolymers of glutamic acid and ethyl glutamate were evaluated for their permeability to proteins ranging in molecular weight from 12,300 to 69,000. The results showed that the copolymers were sufficiently permeable that they could be used for the preparation of implantable, controlled-release systems capable of releasing therapeutic amounts of high-molecular-weight drugs.

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