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Controlled Release of Lastet, an Anticancer Drug, From Poly(3-Hydroxybutyrate) Microspheres Containing Acylglycerols

✍ Scribed by Abe, Hideki; Doi, Yoshiharu; Yamamoto, Yuji


Book ID
120824668
Publisher
Taylor and Francis Group
Year
1992
Tongue
English
Weight
360 KB
Volume
29
Category
Article
ISSN
1060-1325

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Drug release was controlled by a combination of prodrug and polymer matrix. Prodrugs of 5-fluoro-2'-deoxyuridine with different physicochemical properties were synthesized by esterification with aliphatic acids (propionate, n-butyrate, and n-pentanoate). Microspheres containing these ester prodrugs