Controlled release of gentamicin from biomimetic calcium phosphate in vitro. Comparison of four different incorporation methods

✍ Scribed by D. Tadic; T. Welzel; P. Seidel; E. Wüst; E. Dingeldein; M. Epple

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 243 KB
• Volume: 35
• Category: Article
• ISSN: 0933-5137
• DOI: 10.1002/mawe.200400841

✦ Synopsis

Abstract

Cylinders of biomimetic (nanocrystalline) calcium phosphate were loaded with gentamicin by four different methods: 1) dip‐coating, 2) impregnation followed by cold‐isostatic pressing, 3) co‐precipitation followed by cold‐isostatic pressing, and 4) coating of co‐precipitated particles with a biodegradable polymer PDLLA (poly‐D,L‐lactide), followed by uniaxial pressing. The release kinetics were studied in vitro over 10 days. The incorporation by methods 2), 3) and 4) showed a significantly higher long‐term release of active gentamicin than dip‐coating, although there was an initial burst during the first two days with all four methods. With method 4), there was an increase of the released gentamicin after 7 days, and the long‐term release was the highest of these four methods. The results are of considerable interest for the preparation of biodegradable bone implants which are loaded with biologically active substances.