Drug release from collagen matrices is in most cases governed by diffusion from swollen matrices but also enzymatic matrix degradation or hydrophobic drug/collagen interactions may contribute. To reduce water uptake and to prolong the release, insoluble collagen matrices have been chemically or dehy
Controlled release of drugs from hydrogel matrices
โ Scribed by Shuntaro Hosaka; Hitoshi Ozawa; Hiroshi Tanzawa
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 546 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0021-8995
No coin nor oath required. For personal study only.
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Phosphorylcholine-functionalized poly-epsilon-caprolactone (PC-PCL) is a new biodegradable polymer with good biocompatibility. In this study modulation of the controlled release of Ibuprofen (IB), a model drug, from poly-epsilon-caprolactone (PCL) by direct blending with PC-PCL is investigated. The
## Abstract **Summary:** The aim of this study was to analyse the influence of the template/functional monomer proportion on the achievement of molecularly imprinted hydrogels with cavities with a high enough affinity for the drug to sustain drug release. Imprinted hydrogels were prepared from __N_