Controlled release of chlorhexidine diacetate from a porous methacrylate system: Supercritical fluid assisted foaming and impregnation
✍ Scribed by K. Gong; M. Braden; M.P. Patel; I.U. Rehman; Z. Zhang; J.A. Darr
- Book ID
- 102397158
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 321 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
The release of chlorhexidine diacetate (CX) from a self-curing polymeric system based on poly(ethylmethacrylate) and tetrahydrofurfurylmethacrylate (PEM/THFM) was developed in this study. Supercritical fluid assisted impregnation and foaming was employed for preparing porous CX-PEM/THFM drug release system. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) show that the crystallinity of CX significantly decreased after supercritical processing, whilst Raman spectroscopy suggested a hydrogen bonding interaction between the CX and PEM in the product. A UV-Vis dissolution study revealed that the drug release rate is almost as seven times faster in the SCF processed drug delivery system than conventional cured samples.