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Controlled Release of a Poorly Water-Soluble Drug from Hot-Melt Extrudates Containing Acrylic Polymers

โœ Scribed by Zhu, Yucun; Shah, Navnit H.; Waseem Malick, A.; Infeld, Martin H.; McGinity, James W.


Book ID
126921535
Publisher
Informa plc
Year
2006
Tongue
English
Weight
369 KB
Volume
32
Category
Article
ISSN
0363-9045

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Sustained-release formulations such as hydroxypropyl methylcellulose (HPMC)based hydrophilic matrix tablets of poorly water-soluble drugs often result in incomplete release because of the poor solubility and dissolution rate of the drug in the hydrophilic matrix. Sulfobutylether-b-cyclodextrins ((SB