Control of drug release with a combinati
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Takeo Kawaguchi; Akiko Tsugane; Kumiko Higashide; Hirotaka Endoh; Tetsuya Hasega
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Article
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1992
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John Wiley and Sons
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English
⚖ 488 KB
👁 1 views
Drug release was controlled by a combination of prodrug and polymer matrix. Prodrugs of 5-fluoro-2'-deoxyuridine with different physicochemical properties were synthesized by esterification with aliphatic acids (propionate, n-butyrate, and n-pentanoate). Microspheres containing these ester prodrugs