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Controlled release of 3′, 5′-diester prodrugs of 5-fluoro-2′-deoxyuridine from poly-L-lactic acid microspheres

✍ Scribed by Toshinobu Seki; Takeo Kawaguchi; Hirotaka Endoh; Kozo Ishikawa; Kazuhiko Juni; Masahiro Nakano


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
347 KB
Volume
79
Category
Article
ISSN
0022-3549

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✍ Takeo Kawaguchi; Akiko Tsugane; Kumiko Higashide; Hirotaka Endoh; Tetsuya Hasega 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 488 KB 👁 1 views

Drug release was controlled by a combination of prodrug and polymer matrix. Prodrugs of 5-fluoro-2'-deoxyuridine with different physicochemical properties were synthesized by esterification with aliphatic acids (propionate, n-butyrate, and n-pentanoate). Microspheres containing these ester prodrugs